Flexible Once-Daily Dosing
Once-daily powder packets available in two strengths for flexible, age- and weight-based adjustments as patients grow1
The recommended dosage of SEPHIENCE is based on age and body weight. The maximum recommended dose for patients is 60 mg/kg/day.1
Slide table to view more
Age
<6 months
6 months to <1 year
1 year to <2 years
≥2 years
Recommended Starting Dose*,†
7.5 mg/kg/day
15 mg/kg/day
30 mg/kg/day
60 mg/kg/day
*For calculated daily doses less than 1000 mg, the final concentration of prepared
SEPHIENCE liquid mixture is 25 mg/mL.1
†60 mg/kg is the maximum daily dose for all patients.1
Dose modifications based on weight are essential to maintain SEPHIENCE effectiveness as patients grow.1
Dosing Calculator
Quickly determine the appropriate once-daily oral dose of SEPHIENCE based on your patient’s age and weight1
Let’s begin
SEPHIENCE is dosed based on the patient’s age and weight. Use this helpful tool to determine the appropriate SEPHIENCE dose for your patients.
Patient Age:
Months
Patient Weight:
kg
Total Dose Per Day (mg)
mg
Administered Dose Volume Per Day:
ml
Total Daily SEPHIENCE:
mg
packet x
The above calculator is provided as a guide for help calculating your patient’s dose (for US healthcare professionals only). The information provided is not intended to supersede independent clinical judgment and calculations should be confirmed.
Made to Mix into Daily Routines with 250 mg and 1000 mg Options1
Prepare
Use individual packets of 250 mg or 1000 mg. Mix the powder with water, apple juice, or a soft food (only for doses ≥1000 mg), such as applesauce or strawberry jam.
Mix
Stir liquids for ≥30 seconds.
Stir soft foods for ≥60 seconds.
Stir until the mixture is uniform.
The oral powder is not expected to dissolve completely.
This is normal.
Administer
Rinse
Rinse the syringe or cup with water or juice, and swallow immediately to ensure the entire dose is delivered. Repeat if particles remain.
Dosing Guidance Overview:
- Titration for Patients <2 Years of Age: After initiating treatment, monitor blood Phe levels within 2 weeks for response to treatment. If Phe levels do not decrease, titrate dosage incrementally up to 60 mg/kg/day based on blood Phe levels. Do not alter dietary protein/Phe intake during this period.1
- Discontinuation: Stop treatment if no blood Phe reduction is seen after 2 weeks at 60 mg/kg/day.1
- Monitoring & Modification: Regularly monitor blood Phe levels. Adjust SEPHIENCE dose (7.5–60 mg/kg/day) and/or diet to maintain control—especially in pediatric patients.1
- Missed Dose: Administer as soon as possible. Do not double up; resume normal schedule next day.1
Please refer to full Prescribing Information, including the Instructions For Use for preparation, administration, and storage details.
Careful mixing, dosing, and rinsing can help minimize the potential for staining from SEPHIENCE; following the instructions helps ensure proper administration.
Dosing & Administration Support
Dosing and Administration Guide
Keep the dosing guide in your office for quick reference during patient care.
Stay informed
Sign up to receive updates, clinical insights, and resources straight to your inbox.
Reference: 1. SEPHIENCE. Package Insert. PTC Therapeutics, Inc; 2025.